Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may well lessen sufentanil ranges and efficacy, perhaps precipitating withdrawal syndrome in individuals who may have designed physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may well boost sufentanil plasma concentration.
There won't be any knowledge on pregnancy exposures in primates corresponding to intervals just before the 3rd trimester in humans.
pentobarbital will lower the level or effect of buprenorphine subdermal implant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Keep an eye on clients by now on buprenorphine subdermal implant who have to have newly-initiated treatment method with CYP3A4 inducer for indications and symptoms of withdrawal.
Scientific studies performed in young animals and youngsters propose repeated or prolonged usage of common anesthetic or sedation drugs in children young than three a long time might have destructive effects on their creating brains. Explore with parents and caregivers the benefits, challenges, and timing and duration of surgical treatment or processes demanding anesthetic and sedation drugs.
Contraindicated (one)pentobarbital will lessen the extent or effect of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Potent or average CYP3A inducers may possibly lessen cobimetinib systemic exposure by >eighty% and lower its efficacy.
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pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may possibly raise the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will decrease the extent or effect of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will lower the extent or effect of levamlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of efavirenz by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will lessen the extent or effect of irinotecan liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will decrease website the extent or effect of dasatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Keep an eye on Closely (1)pentobarbital will lessen the extent or effect of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Warning when discontinuing CYP3A4 inducers that are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may perhaps increase and can lead to most likely lethal respiratory depression.
The sodium salt takes place like a white, marginally bitter powder which happens to be freely soluble in water and alcohol but pretty much insoluble in benzene and ether.